British estate agent Renfield travels to Transylvania to meet with the mysterious Count Dracula, who is interested in leasing a castle in London and is, unbeknownst to Renfield, a vampire. After Dracula enslaves Renfield and drives him to insanity, the pair sail to London together, and as Dracula begins preying on London socialites, the two become the subject of study for a supernaturalist professor, Abraham Van Helsing.
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