Dr Vijay Nambiar (Suresh Gopi) is a famous neurosurgeon. His wife Dr Nalini Nambiar (Abhirami) is a gynecologist in the same hospital. They lead a contented and busy family life. 'Appothikkiri' plots the intriguing issues that affect their life.
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High-school principal Dr. Alfred Carroll relates to an audience of parents that marijuana can have devastating effects on teens: a drug supplier entices several restless teens, Mary and Jimmy Lane, sister and brother, and Bill, Mary's boyfriend, into frequenting a reefer house. Gradually, Bill and Jimmy are drawn into smoking dope, which affects their family lives.
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